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The discovery of antibiotics once revolutionised human medicine. These therapeutic agents were considered the magic bullet to solve all human infections. However, it was not long until it was discovered that microorganisms were resistant to antimicrobials. Although antimicrobial resistance (AMR) is primarily a natural process, the indiscriminate use of antimicrobials in human and animal medicine has exacerbated the situation, making AMR one of the most significant public health challenges the world has faced in recent years. Addressing this ill has been the centre of global discourse. While the human and the veterinary sectors have put in tremendous efforts to curb this challenge, the environmental sector still has a long way to go. Thus, the World Health Organization has proposed the “One Health” approach as the way in which the fight against AMR could be won. Despite this realisation, the environment remains the unattended elephant in the room in this one health triad. Yet, the environmental dimension of AMR is highly affected by human activities such as agriculture, probably because the interaction between AMR in these sectors is not well understood. Thus, understanding how this happens could create greater awareness of the issue, significantly reducing AMR in the environment and protecting human, animal, and environmental health. This presentation will look at some works carried out to attempt to close the knowledge gap.